在MASLD中的免疫病原机制和免疫调节疗法
Yong He1,2, Yingfen Chen3,4, Shengying Qian3,4
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai, China. heyong@simm.ac.cn.
Cellular & molecular immunology
|June 10, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响全球30%的人口,但治疗方法有限. 本综述探讨了驱动MASLD的免疫机制及其向代谢功能障碍相关的脂肪肝炎 (MASH) 的进展.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,是全球最常见的慢性肝病,影响约30%的人.
- MASLD的发病包括过度营养,遗传因素,肝细胞损伤和肝炎,炎症导致进展为脂肪肝炎和纤维化.
- 目前的MASH疗法针对的是代谢损伤,但不是直接针对炎症,这凸显了需要改进理解和治疗策略的需要.
研究的目的:
- 审查目前有关MASLD背后的免疫机制的数据.
- 总结现有和实验性疗法对MASLD免疫调节的影响.
主要方法:
- 在MASLD中的免疫机制的文献综述.
- 对免疫调节的当前和实验性治疗效应的分析.
主要成果:
- 肝脏炎症是MASLD从简单的脂肪酸炎到脂肪肝炎和纤维化进展的关键因素.
- 现有的MASH治疗方法,如resmetirom和incretin模拟剂,主要针对代谢方面,而不是直接治疗炎症.
- 新兴的研究重点是了解免疫路径,以开发向的抗炎疗法.
结论:
- 更深入地了解MASLD的免疫驱动因素对于开发有效治疗至关重要.
- 针对肝炎的治疗代表了对MASLD和MASH的有希望的治疗途径.
- 未来的研究应该专注于免疫调节策略,以打击MASLD的进展.
相关概念视频
01:40Cell-mediated Immune Responses
67.7K
Overview
67.7K
01:24T Cell Types and Functions
959
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
959
01:25Immunodeficiency Diseases
916
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
916
01:27Tumor Immunotherapy
489
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
489
01:24B Cell Activation and Differentiation
1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
143
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
143