尼梅苏利德和氨酸可以改善创伤性膝关节骨关节炎的炎症过程和疼痛严重程度
Wei Wang1, Yao Du2, Xiaohe Zhang3
1Second Department of Orthopedics, Zhongxian People's Hospital, Chongqing, 404300, China.
Inflammopharmacology
|June 10, 2025
概括
将口服尼梅苏利德与氨酸注射相结合,可显著减少创伤性膝关节关节炎 (TKO) 的疼痛和炎症标志物. 与单独使用尼梅苏利德相比,这种联合治疗改善了身体功能和整体临床疗效.
科学领域:
- 整形外科 整形外科 整形外科
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 创伤性膝关节关节炎 (TKO) 是一个重大的临床挑战.
- 炎症因素如MMP-3,MMP-9,IL-1和TNF-α在TKO病变发生过程中起着至关重要的作用.
- 持续寻求TKO有效的管理策略.
研究的目的:
- 评估TKO患者口服尼梅苏利德和关节内氨酸联合治疗的疗效.
- 评估这种联合治疗对关键炎症标志物和疼痛强度的影响.
- 为了比较临床结果与单独使用口服尼梅苏利德的标准治疗.
主要方法:
- 一个随机对照试验,涉及100名TKO患者.
- 实验组接受了口服尼梅苏利德持续释放囊以及关节内氨酸.
- 对照组仅接受了口服尼梅苏利德持续释放囊.
- 测量结果包括视觉模拟量表 (VAS),WOMAC评分,炎症标志物,生活质量和临床疗效.
主要成果:
- 组合治疗组在治疗后显示出明显较低的VAS和WOMAC得分 (P <0.05).
- 在组合组中,MMP-3,MMP-9,IL-1和TNF-α的关节液水平显著降低 (P <0.05).
- 综合治疗效果和生活质量评分 (身体功能,社会功能,心理健康) 在组合组显著更高.
结论:
- 结合口服尼梅苏利德和关节内氨酸是TKO的有效治疗方法.
- 这种治疗方法显著缓解疼痛,并减少关节炎的严重程度.
- 组合疗法增强了临床疗效,改善了患者的生活质量.
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