患有重大脏异常的儿童患病率:一项基于欧洲人口的研究
Ester Garne1, Mads Damkjær2, Anke Rissmann3
1Department of Paediatrics and Adolescent Medicine, Lillebaelt Hospital, University Hospital of Southern Denmark, Sygehusvej 24, 6000, Kolding, Denmark. Ester.garne@rsyd.dk.
European journal of pediatrics
|June 10, 2025
概括
患有先天性水性和多囊性病 (MCKD) 的儿童患衰竭的风险较低. 后尿道 (PUV) 显著增加患病率,其中18.3%的儿童在5岁之前被诊断患有功能衰竭.
科学领域:
- 儿科脏病学 儿科脏病学
- 遗传异常是一种先天性异常.
- 流行病学 流行病学
背景情况:
- 先天性异性是儿科末期病的主要原因.
- 有限的长期数据存在于药物使用和脏结果的儿童与水,MCKD,和PUV.
研究的目的:
- 调查诊断为患有先天性水缩,MCKD或PUV的儿童的预后和长期结果.
- 为父母咨询提供必要的数据,以便在先天性脏异常的产前诊断后提供必要的数据.
主要方法:
- 一项基于人口的研究,利用来自九个欧洲先天性异常登记处的数据 (1995-2014).
- 包括被诊断患有先天性水性,MCKD或PUV的儿童和参考儿童.
- 数据链接到处方和医院数据库,用于药物使用,诊断和程序,直到10岁.
主要成果:
- 患有水性或MCKD的儿童在10岁之前服用抗高血压药物的可能性增加了13倍.
- 大约3%的水缩或MCKD儿童在5岁时经历了衰竭,其中1%接受了移植.
- 相比之下,18.3%的PUV儿童在5岁时被诊断出患有衰竭,5%的儿童接受了移植.
结论:
- 患有 kongenital hydronephrosis和MCKD的儿童通常面临衰竭的绝对风险很低.
- 后尿道 (PUV) 与明显更高的发病率有关,其中很大一部分在生命早期患有功能衰竭.
- 在幼儿时期密切监测患有PUV的儿童对于预防或延迟功能衰竭至关重要.
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