病前营养状况对结核病严重程度的影响
A Tabackman1, A N Gupte2, B Thangakunam3
1Boston Medical Center, Boston, MA, USA.
概括
结核病 (TB) 发病前的营养不良显著增加了严重肺部疾病的风险,包括空洞化和更大的肺部参与. 营养干预对于减轻结核病严重程度和改善患者治疗结果至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 营养科学 营养科学
背景情况:
- 全球范围内,营养不良是结核病 (TB) 的首要危险因素.
- 它与更糟糕的结核病结局和更高的死亡率有关.
- 这项研究调查了结核病前营养状况对疾病严重程度的影响.
研究的目的:
- 评估结核病发病前的营养不良如何影响结核病严重程度的放射和微生物标志物.
- 分析低体重指数 (BMI) 和结核病进展之间的关系.
主要方法:
- 来自RePORT印度联盟 (2015-2019) 肺结核确诊患者的个人前性队列分析.
- 暴露被定义为在结核病发作之前的中度至严重营养不良 (BMI <17 kg/m2).
- 评估的结果包括肺腔,唾液涂抹的阳性,肺部参与程度和阳性时间.
主要成果:
- 14.2%的参与者 (226/1,587) 在结核病发作之前营养不良.
- 营养不良与肺部腔化 (aOR 1.80) 和更大的肺部参与率增加有关.
- 一般化添加模型表明BMI和空洞化之间存在非线性关系.
结论:
- 结核病发病前的营养不良是严重肺结核的重要预测因素.
- 解决营养状况对于减少结核病的严重程度和改善治疗结果至关重要.
- 强调营养支持在结核病管理战略中的重要性.
更多相关视频
09:34An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
1.8K
03:35Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
Published on: December 1, 2023
279
相关概念视频
Pulmonary Tuberculosis I
221
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
221
Pulmonary Tuberculosis V
170
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
170
Pulmonary Tuberculosis IV
134
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
134
Pulmonary Tuberculosis III
312
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
312
Pulmonary Tuberculosis II
213
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
213
Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K
