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Updated: May 8, 2026

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高分辨率检测RPS24微埃克森变异揭示了针对肺腺癌的KRAS向治疗的新型拼接模式

Dahye Nam, Bin Tian, Jiyeon Park

  • 1Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 06591; Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

BMB reports
|June 11, 2025
PubMed
概括

我们开发了一种新方法来检测Ribosomal Protein 24 (RPS24) 微表子中的替代拼接 (AS) 变异. 在肺癌中,RPS24 3 bp异型可能作为KRAS抑制剂反应的生物标志物.

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相关概念视频

The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...