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在各种光学连贯性断层扫描系统中对状毛囊视觉化的比较分析

Semenova Nataliya¹, Stulova Anna¹, Akopyan Vladimir¹

¹Lomonosov Moscow State University, School of Medicine, Department of Ophthalmology, Moscow, Russian Federation.

European journal of ophthalmology

|June 11, 2025

概括

光学连贯断层扫描血管造影 (OCTA) 系统在测量胆囊细胞 (CC) 血流量方面表现出显著的变化. 特定于设备的算法对于准确的CC评估和定量数据的解释至关重要.

科学领域:

眼科医生眼科眼科
生物医学工程生物医学工程
医疗成像医学成像

背景情况:

皮细胞 (CC) 血流对于视网膜健康至关重要.
光学连贯断层扫描血管造影 (OCTA) 是CC评估的关键成像方式.
不同OCTA设备之间的CC测量的变化是临床和研究应用的一个问题.

研究的目的:

为了评估多个光学连贯断层扫描血管学 (OCTA) 系统中胆囊细胞 (CC) 血流量测量的变化.
为了比较从不同的OCTA设备获得的定量CC流量参数.

主要方法:

一项涉及13名健康志愿者的横截面研究.
使用六种不同的OCTA系统 (Spectralis,Topcon,Moptim,Optovue,Optopol) 获得了中央3x3毫米的OCTA图像.
用Phansalkar方法分析皮细胞流量缺陷 (FD) 数量,密度和平均FD面积,并使用特定于设备的二元化和值.

主要成果:

在评估的OCTA设备中观察到CC流量缺陷数,密度和平均面积的显著变化 (p < 0.001).
只有在Optovue Avanti和Topcon DRI OCT Triton (v1.38) 之间,对于FD数量 (r=0.955) 和FD密度 (r=0.912) 之间才发现强烈的相关性.
类内相关系数 (ICC) 分析表明不同OCTA设备之间的一致性较差.

结论:

在OCTA系统之间存在CC可视化和量化方面的实质差异,突出了当前的局限性.
为了准确的CC评估,需要开发和实施特定于设备的算法.
来自OCTA的定量CC评估应谨慎解释,因为设备间的变化.

关键词:

一个叫做Choriocapillaris的小鱼儿.潘萨尔卡尔当地值方法流量赤字流量赤字光学连贯性断层扫描血管图谱

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