长期的视觉结果和视网膜功能,有或没有眼睛的视窗内治疗,有中枢视网膜静脉封闭
Monika Meinert1, Elisabeth Wittström1
1Department of Clinical Sciences, Skane University Hospital, Lund University, Lund, Sweden.
European journal of ophthalmology
|June 11, 2025
概括
静脉内注射改善了眼睛的视力,其中有中枢视网膜静脉封闭 (CRVO) 和黄斑胀. 然而,治疗和未治疗的CRVO眼睛都显示长期减少了视网膜功能.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 血管医学 血管医学
背景情况:
- 中央视网膜静脉封闭 (CRVO) 是一种严重影响视力的疾病.
- 黄斑是CRVO的一个常见并发症.
- 抗血管内皮生长因子 (anti-VEGF) 疗法用于治疗与年龄有关的湿斑变性和其他视网膜疾病.
研究的目的:
- 评估静脉内注射对视觉结果,视网膜功能和CRVO眼睛的结构的长期影响.
- 为了将这些结果与未经处理的CRVO眼睛进行比较.
- 为了确定抗VEGF对CRVO光受体细胞功能的长期影响.
主要方法:
- 对38名CRVO患者 (28名接受治疗,10名未接受治疗) 的回顾性研究.
- 在基线 (ERGI) 和随访 (ERGII) 时进行的全场电网膜学 (ERG).
- 视力敏度 (ETDRS字母得分),中骨厚度 (CFT) 和ERG参数在不同组之间的比较.
主要成果:
- 治疗组在ETDRS字母得分上显著改善 (p=0.026).
- 在治疗和未治疗组中,CFT显著下降.
- 两组人均从ERGI到ERGII的a和b波幅显著下降,这表明视网膜功能下降.
结论:
- 静脉内注射改善了CRVO眼睛的长期视觉结果与黄斑胀.
- 虽然CFT有所改善,但在CRVO诊断后四年,治疗和未治疗的眼睛中,视网膜功能仍然下降.
- CRVO的自然过程显著影响长期的视网膜功能.
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