C-C 化学因子受体2 是腹腔大动脉动脉瘤和闭塞性疾病的组织生物标志物
Shahab Hafezi1, Batool Arif1, Rajrani Ruhel2
1Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Annals of surgery
|June 11, 2025
概括
在患有大动脉组织,特别是腹部大动脉动脉瘤 (AAA) 中,C-C 化学因受体2 (CCR2) 升高. 这表明CCR2是监测AAA进展和指导新疗法的潜在生物标志物.
科学领域:
- 血管生物学 血管生物学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 腹腔大动脉瘤 (AAA) 缺乏可靠的组织生物标志物来评估进展和破裂风险.
- 炎症是AAA病原体的核心,这表明与免疫细胞相关的标记物至关重要.
研究的目的:
- 为了确定是否CC化学因子受体2 (CCR2) 作为一个组织生物标志物用于大动脉疾病严重程度,专注于AAA.
- 研究CCR2在AAA病原发生中的作用及其作为预测标记物的潜力.
主要方法:
- 分析了42个人的大动脉组织 (AAA,破裂的AAA,大动脉封闭性疾病,正常的大动脉).
- 在大动脉壁中的CCR2-阳性细胞,MCP1和炎症性细胞因子的量化.
- 单细胞RNA测序以评估AAA组织中的Ccr2表达模式.
主要成果:
- 动脉瘤主动脉 (AAA,rAAA) 与正常主动脉相比,显示出显著更高的CRR2阳性细胞含量.
- 在AAA,rAAA和AOD组织中发现了高的CCR2阳性巨细胞.
- 在患病的大动脉组织中观察到更高水平的MCP1和炎症性细胞因子;Ccr2主要由AAA中的巨体表达.
结论:
- CCR2是患有大动脉组织的有希望的生物标志物,特别是在腹部大动脉动脉瘤 (AAA) 中.
- 这些发现支持CCR2的分子成像潜力,以及作为大动脉疾病中药理干预的目标.
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