在患有轻度认知障碍的患者中,轻度行为障碍和外周血液生物标志物的相关性
Wei Liang1,2, Lan Wang1,3, Mei Song1
1Mental Health Center, The First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei Province, China.
World journal of psychiatry
|June 11, 2025
概括
轻度行为障碍 (MBI) 在轻度认知障碍 (MCI) 和健康老年人 (HOA) 的老年人中更为常见. MBI与阿尔茨海默病的生物标志物有关,这表明它可能预测认知能力下降.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物研究 生物标志物研究
背景情况:
- 轻度行为障碍 (MBI) 包含老年人的神经行为症状,可能表明神经退行性疾病的风险.
- 关于MBI的研究主要集中在脑脊液上,对血生物标志物的研究有限.
研究的目的:
- 确定MBI在健康的老年人 (HOAs) 和轻度认知障碍 (MCI) 个体中的患病率.
- 调查MBI和与阿尔茨海默病 (AD) 相关的血生物标志物之间的关联.
主要方法:
- 241名受试者 (136名HOA,105名MCI) 使用MBI-C检查清单 (得分≥6.5) 进行MBI评估.
- 粉样β蛋白 (Aβ) 40,Aβ42和高酸化陶蛋白 (p-Tau217) 的血水平通过ELISA测量在70名参与者的子集中.
主要成果:
- 在HOA中,MBI的患病率为4.4%,在MCI中为15.3% (P=0.007).
- 常见的MBI症状包括动机下降,冲动失控增加,以及社会不合适.
- MBI得分与Aβ42和p-Tau217水平相关 (P<0.05),冲动失控与Aβ42特别相关.
结论:
- 在MCI和HOA中,MBI普遍存在,经常表现为冲动控制问题.
- MBI是认知能力下降的独立风险因素,与外围阿尔茨海默病生物标志物有关.
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