在急性胰腺炎患者中,估计的血体积状态与急性损伤之间的非线性关联
Wen Wu1,2,3,4, Yu-Pei Zhang1,2, Yi-Lan Zhang1,2
1Department of Emergency and Critical Care Medicine, Yichang Central People's Hospital, Yichang 443000, Hubei Province, China.
World journal of gastroenterology
|June 11, 2025
概括
估计血体积状态 (ePVS) 显示在急性胰腺炎 (AP) 患者中与急性损伤 (AKI) 有非线性关联. 确定了U形和J形曲线,表明特定的ePVS范围增加了AKI风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 胃肠病学 胃肠病学
- 关键护理医学 关键护理医学
背景情况:
- 急性胰腺炎 (AP) 是一种严重的炎症状况,患病率不断增加,死亡率显著.
- 急性损伤 (AKI) 是AP的常见和危险并发症,与高死亡率有关.
- 了解AP中AKI的预测因素对于改善患者的治疗结果至关重要.
研究的目的:
- 评估估计血体积状态 (ePVS) 在预测AP患者的AKI中的有效性.
- 调查ePVS和AKI发展之间的关系.
- 根据ePVS.识别基于AKI风险的潜在门.
主要方法:
- 对1508名AP患者进行了回顾性队列研究.
- 从电子医疗记录中提取的数据,包括人口统计和临床特征.
- 多变量逻辑回归和非线性曲线拟合用于分析ePVS和AKI之间的关联.
主要成果:
- 16.6%的AP患者发生了AKI.
- 杜阿尔特-ePVS (D-ePVS) 和卡普兰-哈基姆-ePVS (KH-ePVS) 的低和高三位数与参考三位数相比,与增加的AKI风险有关.
- 观察到非线性关联:D-ePVS的U形 (屈曲点4.3dL/g) 和KH-ePVS的J形 (屈曲点-2.8%).
结论:
- 估计的血体积状态 (ePVS) 表明与AP患者的AKI发病率存在非线性关联.
- 特定的ePVS范围,通过U形 (杜阿尔特公式) 和J形 (卡普兰-哈基姆公式) 曲线确定,与AKI风险增加有关.
- 这些发现表明,ePVS可以成为预测AP中的AKI的有价值工具.
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