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乌帕达西提尼布治疗性结肠炎和皮肤质性病的精神分裂症患者长期服用RISPERIDONE:一个病例报告
1Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China.
World journal of gastroenterology
|June 11, 2025
概括
在患有精神分裂症的患者中,upadacitinib有效地治疗了耐火性性结肠炎 (UC) 和皮肤质性结肠炎 (PG),显示完全治愈,没有副作用. 这为复杂病例提供了新的治疗选择.
科学领域:
- 胃肠病学 胃肠病学
- 皮肤病学 皮肤病学
- 精神病学是一个精神病学.
背景情况:
- 皮肤炎 (PG) 是性结肠炎 (UC) 的一种严重的肠外表现.
- 用PG治疗耐火性UC,特别是在长期服用Risperidone的精神分裂症 (SCZ) 患者中,具有挑战性.
- 对于这种特定的患者资料,没有报告成功的治疗结果.
研究的目的:
- 报告患有新发性UC,PG和SCZ病史的患者的成功治疗结果.
- 评估upadacitinib在复杂患者病例中治疗耐火性UC和PG的疗效和安全性.
- 评估同时使用upadacitinib和risperidone的安全性.
主要方法:
- 一名36岁的女性患者有SCZ病史,长期使用Risperidone,被诊断为中度UC.
- 在UC复发后,患者在两个下肢中发展了PG,之前的治疗 (adalimumab,类固醇) 证明是无效的.
- 治疗被切换为upadacitinib (UPA) 45毫克/天,随后通过结肠镜监测PG愈合,便calprotectin和粘膜愈合.
主要成果:
- 在7周内,Upadacitinib治疗导致PG病变完全愈合.
- 便中的calprotectin水平降至<10μg/g,表明肠道炎症减少.
- 12周后的结肠镜证实了UC的粘膜愈合,在6个月的UPA和RISPERIDONE同时治疗期间没有报告任何不良事件.
结论:
- 在这个病人身上,upadacitinib有效地解决了肠道 (UC) 和肠外 (PG) 症状.
- 同时使用upadacitinib和risperidone是安全的,并且耐受良好.
- 这一案例表明upadacitinib是SCZ患者耐火性UC与PG的潜在治疗选择.
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