心房动是否会增加骨折的风险? 一个系统的审查和元分析
Wei Chen1,2, Yuyu Zhang1, Huaze Xie1,3
1Department of General Practice, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shannxi, China.
Frontiers in medicine
|June 11, 2025
概括
心房动 (AF) 整体上没有显著增加骨折风险. 然而,亚裔AF个体的骨折倾向较高,这表明人口特异性关联.
科学领域:
- 心脏病学 心脏病学
- 整形外科 整形外科 整形外科
- 流行病学 流行病学
背景情况:
- 临床观察表明,心房动和骨折之间存在联系.
- 心房动和骨折风险之间的关系需要进一步研究.
研究的目的:
- 进行一项元分析,调查心房动与骨折风险之间的关联.
主要方法:
- 搜索了PubMed和Cochrane图书馆的队列研究,比较AF患者与对照者的骨折患病率.
- 包括5个队列研究,共有187,868名参与者.
主要成果:
- 总的来说,在心房的患者中没有观察到统计学上显著的骨折风险增加 (OR = 1.17,P = 0.65).
- 亚组分析显示,亚洲人群中心房动的骨折风险明显较高 (OR = 1.61,P < 0.00001).
- 在高加索人群中没有发现显著的关联 (OR = 0.94,P = 0.92).
结论:
- 心房动与亚洲人群中骨折风险增加有关.
- 进一步的研究可能会阐明种族特异性风险因素和机制.
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