在两名患有普拉德-威利综合征的成年人中,塞特拉林诱导的情绪和行为激活
1Pittsburgh Partnership, Specialists in PWS, Pittsburgh, Pennsylvania, USA.
Case reports in psychiatry
|June 11, 2025
概括
选择性血清素再吸收抑制剂 (SSRI),如塞特拉林,在患有普拉德-威利综合征 (PWS) 的个体中可以引起情绪和行为激活 (MBA). 停止使用SSRI解决了MBA,强调需要在PWS患者中仔细考虑药物基因组.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 普拉德-威利综合征 (PWS) 与由于选择性血清素再吸收抑制剂 (SSRI) 的情绪和行为激活 (MBA) 的高风险有关.
- 遗传和表观遗传因素,包括PWS分子亚型,如母性单亲分裂症 (mUPD),影响SSRI反应.
- 患有mUPD的个体在30岁前出现双相情感障碍的风险>60%.
研究的目的:
- 呈现两例PWS (mUPD) 的成年人中MBA的病例,他们接受了对焦虑的塞特拉林治疗.
- 要突出SSRI在这个患者群体中的潜在风险.
主要方法:
- 病例报告以文献审查,临床经验和行为数据为依据.
- 获得了患者同意和父母同意.
主要成果:
- 两名患有mUPD的成人PWS患者在一年内通过增加塞特拉林剂量开发了MBA.
- 症状包括易怒,睡眠障碍和增加的吞,由COVID-19压力因素加剧.
- 在停止服用塞特拉林后,MBA得到解决,需要使用情绪稳定剂来恢复基线.
结论:
- 塞特拉林和其他SSRI可以在PWS患者中诱导MBA,即使是标准剂量.
- 风险随着较高的SSRI剂量而增加,并受到年龄和PWS遗传亚型的影响.
- 药基因组测试对于指导PWS患者的SSRI选择,剂量和管理至关重要.
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