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DGM-TOP:自动识别心房慢心的临界边界

Robin Van Den Abeele¹, Sander Hendrickx¹, Niels Carlier¹

¹Department of Physics and Astronomy, Ghent University, Ghent, Belgium.

Frontiers in physiology

|June 11, 2025

概括

心律不整的拓学揭示了关键边界维持了回入性心房止痛 (AT). 将这些边界与废除线连接在一起,有效地终止了AT,指导了精确的处理策略.

科学领域:

心脏病学心脏病学
计算生物学计算生物学
医学物理医学物理

背景情况:

基于重新进入的心房性心跳动 (AT) 是复杂的心律失常症.
索引定理为理解AT维护提供了一个数学框架.
由拓电荷定义的临界边界是AT机制的关键.

研究的目的:

介绍和验证DGM-TOP算法用于计算解剖边界的拓电荷.
证明在性心脏和临床心房动脉动脉动症中一致检测临界边界.
确认关键边界相互连接的必要性,以通过消去成功地终止AT.

主要方法:

开发了DGM-TOP算法,用于分析电解剖图和识别关键边界.
通过加算局部激活时间差异并根据周期长度进行正常化来计算拓电荷.
验证了 578 个性心脏病例和 24 个临床心脏病例的算法和切除策略.

主要成果:

该DGM-TOP算法成功地确定了100%分析的心房高心率的临界边界.
连接两个关键边界的废除策略始终终止了AT.
不连接关键边界的剥离线未能终止AT,这强调了精确准的重要性.

结论:

使用索引定理的拓分析准确地识别了维护重新进入的AT所必需的关键边界.
连接关键边界的有针对性的切除是终止心房高心率的高度有效策略.
需要进一步改进算法,如BCL算法,以及更大的临床数据集,以改进高心律周期长度预测.

关键词:

切除 < 电生理学心动脉短心 (AT) 是一种心脏病.临床分析临床分析模拟 - 计算机 - 计算机拓学的拓学

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