循环microRNAs在预测纤维化在多变性心肌病:一个系统的审查
Maneeth Mylavarapu1, Lakshmi Sai Meghana Kodali2, Roopeessh Vempati3
1Public Health, Adelphi University, Garden City, NY 11530, United States.
World journal of cardiology
|June 11, 2025
概括
特定的循环microRNAs (miRNAs) 显示出作为检测心肌纤维化在多变性心肌病 (HCM) 的非侵入性生物标志物的承诺. 高水平的miR-21和miR-29a与HCM患者的纤维化程度相关.
科学领域:
- 生物标志物 生物标志物
- 心血管研究研究心血管研究
- 分子诊断学 分子诊断
背景情况:
- 缩性心肌病 (HCM) 涉及左心室缩和纤维化,导致不良后果.
- 心脏磁共振 (CMR) 检测纤维化,但循环中的微RNA (miRNA) 提供了一个稳定的,非侵入性的生物标志物替代品.
研究的目的:
- 研究循环miRNAs作为心肌纤维化在HCM患者的潜在生物标志物.
- 为了确定与HCM纤维化相关的特定miRNAs.
主要方法:
- 2014-2024年对miRNAs和HCM纤维化研究的系统文献综述.
- 包括测量HCM患者血液中miRNA表达的研究和通过成像 (主要是CMR) 评估纤维化.
- 提取了关于人口,方法和miRNA水平与纤维化之间的相关性数据.
主要成果:
- 七项研究 (365名HCM患者) 确定了miR-21,miR-29a,miR-133,miR-4454和miR-221作为失调的标记物.
- 升高的miR-21和miR-29a水平与CMR纤维化增加相关.
- miR-29a在HCM中始终与纤维化和缩有关.
结论:
- 循环中的miRNAs,特别是miR-21,miR-29a和miR-221,是与HCM相关的心肌纤维化有前途的生物标志物.
- 需要进一步的研究来验证这些发现,并探索miRNA诊断在HCM的临床应用.
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