病例报告:丸腺瘤对儿童丸内分泌功能的影响
Yan Li1, Junfeng Zhao1, Yi Chen1
1Department of Pediatrics Surgery, Women and Children's Hospital of Ningbo University, Ningbo, Zhejiang, China.
Frontiers in endocrinology
|June 11, 2025
概括
儿童腺瘤很少见,但可能会影响丸功能. 对这种良性瘤的幸存者来说,对激素和丸体积的长度监测至关重要.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 腺体瘤是罕见的,良性中瘤,主要影响生殖道,是前质群体的常见原因.
- 虽然通常在成年人中被诊断出来,但儿科病例非常罕见,往往导致诊断模两可和潜在的花切除术.
研究的目的:
- 为了研究长期的丸功能在儿科患者后保守切除一个帕伦基马腺形瘤.
- 确定序列激素和丸体积测量的实用性,用于监测儿科幸存者的丸健康.
主要方法:
- 这是一项为期5年的前性研究,涉及血清激素 (FSH,LH,丸激素,B抑制素,AMH) 和双侧丸体积的连续测量.
- 使用MRI进行初始质量识别和手术内冷部位分析进行诊断.
主要成果:
- 受影响的丸显示出显著的补偿性缩 (体积增加2.1倍).
- 关键的荷尔蒙标志物,包括抗穆勒尔激素 (AMH) 和B抑制素 (INHB),在手术后呈现下降,随着时间的推移,部分恢复.
- FSH,LH和的水平保持在青春期前的范围内,这表明荷尔蒙轴保留,但潜在的塞尔托利细胞功能障碍.
结论:
- 儿科腺瘤瘤幸存者在塞尔托利细胞功能中呈现逐渐下降,通过对INHB,AMH和丸体积的纵向监测来检测到.
- 保守切除,以冷截面分析为指导,有效地保护丸并防止花切除.
- 生物标志物监测对于早期检测丸功能障碍至关重要,使得儿童幸存者能够及时干预.
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