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Updated: Jun 14, 2025

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Published on: January 16, 2017

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在HELB基因中的罕见SNP干扰RPA相互作用和HELB的细胞功能

Bertha Osei1, Benjamin H May1, Joseph S Beard1

  • 1Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.

NAR molecular medicine
|June 11, 2025
PubMed
概括

人类螺旋酶HELB中的一个特定基因变异 (rs75770066) 通过减少与RPA的相互作用,损害了其DNA修复功能. 这导致DNA修复发生改变,影响性质组的生存能力,并可能影响自然更年期的年龄.

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