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身体完整性障碍症的隐藏面:对动态触摸有异常的边缘反应

Laura Zapparoli^1,2, Eraldo Paulesu^1,2, Martina Gandola^3,4,5

¹Psychology Department and NeuroMi-Milan Centre for Neuroscience, University of Milano-Bicocca, Milan 20126, Italy.

Brain communications

|June 11, 2025

概括

身体完整性障碍症 (BID) 涉及对截肢的强烈渴望,与大脑活动的改变有关. 这项研究揭示了在刺激所需的截肢部位时,双侧创伤患者的奖励和疼痛系统激活的增加.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

身体完整性障碍症 (BID) 是一种基于大脑的疾病,其特点是持续渴望截肢健康的四肢.
以前的研究表明,BID患者体感皮层的功能连接性发生变化.
基础的神经生理机制,特别是与BID相关的痛苦,仍然不太了解.

研究的目的:

在对所需的截肢部位的体感刺激过程中,研究BID患者的脑活动.
探索改变的身体地图,大脑的奖励系统和BID中经历的痛苦之间的关系.

主要方法:

功能性磁共振成像 (fMRI) 用于研究终身渴望截肢左腿的个体.
动态体感刺激模式应用于下肢,专注于所需的截肢线.
参与者检测到刺激越过标记的截肢线时,与健康对照者相比,大脑激活.

主要成果:

患有BID的个体在激发左腿时,表现出奖励和与疼痛相关的网络中神经激活的增加.
这些过度激活在刺激越过所需的截肢线后立即表现最为明显.
运动前皮层和前带带皮层的激活增加表明在截肢点的注意力兴奋增加.

结论:

这项研究表明,在BID中,改变的身体地图表示和大脑的奖励系统之间存在病理联系.
这些发现将BID与内脏大脑联系起来,为该疾病的神经生物学基础提供了新的见解.
这项研究为身体完整性障碍症患者所经历的痛苦提供了神经生理学上的解释.

关键词:

身体完整性障碍症身体完整性障碍症身体所有权身体所有权功能磁力共振成像 (fMRI) 是一种触觉刺激是一种触觉刺激.异国情调的异国情调是什么

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