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将诊断钉在钉子上:在PLHIV中,拉米武丁诱导的围性热性颗粒瘤

Karthick Kumar Vaitheeswaran¹, Neeraj Nischal¹, Neetu Bhari²

¹Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

|June 11, 2025

概括

这项案例研究确定了拉米武丁作为艾滋病毒阳性患者周口炎热原性颗粒瘤的潜在原因. 修改抗逆转录病毒疗法导致病变的消失,突出显示了药物诱导的热性颗粒瘤管理的重要性.

科学领域:

皮肤病学皮肤病学
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

发热性颗粒瘤 (PG) 或球状毛细血管血栓瘤是一种良性血管瘤.
周口PGs是一种独特的形式,通常与药物有关,包括抗逆转录病毒药物.
接受抗逆转录病毒治疗 (ART) 的HIV阳性个体可能会发生药物诱导的PG.

研究的目的:

在艾滋病毒阳性患者中报告可能由拉米武丁诱导的围性热性颗粒瘤病例.
讨论药物诱导的围性PG的诊断挑战和管理.
强调ART修改对治疗药物相关PG的重要性.

主要方法:

一个临床案例是一个30岁的HIV阳性男性,手指尖和脚有痛苦的病变.
诊断工作包括活检,巴托内拉血清学和组织PCR,以排除其他疾病.
治疗包括局部治疗,脱bridement,以及随后的高度活性抗逆转录病毒疗法 (HAART) 的修改.

主要成果:

组织病理学检查证实了发热性颗粒瘤.
巴托内拉和病毒研究是负面的,不包括细菌性血管瘤和卡波西肉瘤.
停用拉米武丁和ART修改导致半年内周口病变几乎完全消失.

结论:

拉米武丁是一种潜在的药物诱导的外管炎原性颗粒瘤的致病因子.
药物相关PG的有效管理需要仔细考虑ART疗程.
修改ART对于解决药物诱导的周管炎原性颗粒瘤和改善患者的治疗结果至关重要.

关键词:

艺术艺术艺术艺术拉米武丁 (Lamivudine) 的使用情况状毛细血管血栓瘤是什么意思在 PLHIV HIV 中.帕罗尼基亚 (Paronychiachia) 是一个发烧性颗粒瘤是一种可燃性颗粒瘤.

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