相关实验视频

Updated: Jun 13, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

长期COVID-19自身抗体及其对生育能力的潜在影响

Laura Talamini¹, Dennyson Leandro M Fonseca², Darja Kanduc³

¹CNRS UMR7242 Biotechnology and Cell Signalling, University of Strasbourg/Strasbourg Drug Discovery and Development Institute (IMS), Strasbourg, France.

Frontiers in immunology

|June 11, 2025

概括

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染可能会由于交叉反应性免疫反应影响男性生育能力. 针对SARS-CoV-2的抗体也可能与精子蛋白反应,可能影响生殖功能.

科学领域:

免疫学免疫学免疫学
生殖生物学生殖生物学
病毒学病毒学

背景情况:

在COVID-19患者中注意到精子发生障碍,但SARS-CoV-2对男性生育能力的确切影响尚不清楚.
这项研究探讨了将SARS-CoV-2感染与男性生殖功能障碍联系在一起的潜在机制.

研究的目的:

为了研究SARS-CoV-2感染对男性生育能力的影响.
确定感染后男性生殖功能受损的潜在原因.

主要方法:

在基分析中识别SARS-CoV-2尖端蛋白和精子生成蛋白之间共享的氨基酸序列.
用来自COVID-19患者 (急性和长期COVID-19综合征) 和接种疫苗的人的血清测试合成.
在小鼠中进行免疫性和致病性研究,包括对抗体与丸组织相互作用的试验.

主要成果:

感染SARS-CoV-2的患者对特定 (4) 呈现出高抗体反应性.
长期COVID-19综合征患者,特别是女性,对另一种 (2) 的抗体水平升高.
2抗体与小鼠丸组织抗原在体外表现出特定的相互作用.

结论:

在SARS-CoV-2尖端蛋白和精子生成抗原之间的交叉反应表位可能会影响男性生育能力.
由SARS-CoV-2感染引发的潜在自身免疫反应可能会对人类生育产生影响.
需要进一步的研究来证实SARS-CoV-2,自身免疫和男性不孕症之间的直接联系.

关键词:

这是自抗体的自抗体.冠状病毒感染冠状病毒感染男人生殖系统的男性生殖系统.酸序列的身份认同.这是COVID-19后的情况.

更多相关视频

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

相关概念视频

Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

Spermatogenesis

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...