性结肠炎中的结肠直肠癌风险:一个更新的基于人口的系统性审查和元分析
Lechang Zhang1, Xiaohua Zhang1, Tong Su1
1Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
性结肠炎 (UC) 患者患结肠直肠癌 (CRC) 的风险增加. 这项元分析发现,UC患者的CRC综合发病率为1.47/1000人年,标准发病率 (SIR) 为2.48.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 性结肠炎 (UC) 患者面临着显著更高的结肠直肠癌 (CRC) 风险.
- 目前对UC种群中CRC风险的估计有所不同,因此需要更新的基于人口的数据.
研究的目的:
- 提供当前的,基于人群的CRC发病率估计,标准化发病率 (SIR) 和UC患者的患病率.
- 综合高质量研究的数据,以建立可靠的UC相关CRC风险基准.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行了系统的文献搜索,截至2025年4月12日.
- 包括13项高质量的基于人群的研究,涉及161,157名UC患者,其质量通过纽卡斯尔-太华尺度进行评估.
- 使用元分析和元回归来评估CRC风险 (发病率,SIR,流行率) 和研究特征的影响.
主要成果:
- 在UC患者中,CRC的综合发病率为每1000人年1.47 (95%CI为1.30-1.67).
- 在UC患者中,CRC的整体标准化发病率 (SIR) 为2.48 (95%CI为1.64-3.76),表明风险增加2.48倍.
- 估计CRC患病率为1.54% (95%CI为1.14-1.99),广泛性结肠炎 (3.95) 观察到较高的SIR,性别之间的风险相似.
结论:
- 这一元分析为UC患者提供了可靠的,基于人群的CRC风险估计,对临床决策和公共卫生策略有价值.
- 鉴定到的大量异质性和有限的地理多样性 (主要是欧洲) 强调了在代表性不足的地区进行研究的需要.
- 更新的CRC风险数据对于全球UC种群的积极管理和监测至关重要.
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