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在没有糖尿病的成年人中岛屿自身抗体的患病率
Meghan E Pauley1, Kimber M Simmons1, Fran Dong1
1Barbara Davis Center for Diabetes, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Journal of the Endocrine Society
|June 11, 2025
概括
岛屿自身抗体 (IA) 在没有糖尿病的成年人中很常见,特别是在西班牙裔个体中单个IA阳性. 需要进一步的研究,以了解这些成年人的1型糖尿病 (T1D) 的进展.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 糖尿病研究 糖尿病研究
背景情况:
- 1型糖尿病 (T1D) 诊断在成年人中越来越常见,但成年T1D的进展,特别是在没有家族病史的人中,仍然不明确.
- 在没有糖尿病的成年人群中了解小岛自身抗体 (IA) 的患病率对于识别有风险的个体至关重要.
研究的目的:
- 测量科罗拉多州一个没有已知的糖尿病的多元成人群体中小岛自身抗体 (IA) 的流行率.
- 调查IA阳性与人口因素的关联,包括种族/种族和T1D家族病史.
主要方法:
- 儿童自身免疫查研究对1087名成年人进行了针对胰岛素的IA,谷氨酸脱氧化酶 (GADA),小岛抗原-2和载体8的查.
- 在没有已知的糖尿病的成年人中,使用放射结合测定和电化学发光检测方法测量IA,不论家族病史如何.
主要成果:
- 3.86%的成年人对任何IA呈阳性查,其中1.75%对单个IA呈阳性,0.5%对多个IA呈阳性.
- 与非西班牙裔白人成年人相比,西班牙裔成年人更有可能对单个IA呈阳性查 (RR 2.32,P=.001).
- 谷氨酸脱碳酶自身抗体 (GADA) 是最常见的IA,在2.67%的成年参与者中检测到.
结论:
- 在没有被诊断为科罗拉多州糖尿病的成年人中,岛屿自身抗体的患病率是显著的.
- 需要进一步调查,以确定成年人IA阳性测试的临床T1D进展的风险,特别是非家族病例.
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