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在听觉和癌细胞中使用MnTBAP准西斯普拉丁诱导的酸盐应激的差异效应

Shomaila Mehmood¹, Pankaj Bhatia¹, Nicole Doyon-Reale¹

¹Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, USA.

Current research in toxicology

|June 11, 2025

概括

用MnTBAP准酸性压力可以保护听力免受西斯的耳毒性影响,但不会降低其抗癌功效. 这种选择性方法为自我保护提供了一个有希望的策略.

科学领域:

耳鼻和癌症药理学和癌症药理学
生物医学研究的研究.

背景情况:

西斯是一种重要的抗癌药物,但其使用受到耳毒性限制,损害了内耳.
氧化应激和中的蛋白质化是西斯诱导的耳毒性的关键机制.
广泛的抗氧化剂可以降低耳毒性,但也会损害西斯的抗癌作用,需要有针对性的干预措施.

研究的目的:

调查是否选择性抑制酸性应激可以在不影响抗癌活性的情况下预防西斯的耳毒性.
为了评估四氨基乙基 (MnTBAP) 在减轻西斯普拉丁诱导的听觉细胞损伤方面的疗效.

主要方法:

科尔蒂器官和癌细胞用西斯和MnTBAP进行了治疗.
评估了细胞活力,酸性压力标志物,DNA损伤和细胞迁移.
对比了MnTBAP联合治疗对听觉细胞和癌细胞的影响.

主要成果:

西斯普拉丁降低了听觉和癌症细胞中的细胞活力.
与MnTBAP联合治疗显著减轻了听觉细胞中西斯胺诱导的细胞毒性.
MnTBAP没有影响西斯普拉丁对癌细胞的细胞毒性作用.
选择性抑制酸盐应激保护听觉细胞免受西斯普拉丁损伤.

结论:

用MnTBAP向酸盐应激是一种可行的策略,可以预防西斯的耳毒性.
这种选择性方法保留了西斯的抗癌疗效,提供了双重好处.
对酸性压力抑制剂的进一步研究可能会导致改善的癌症疗法,并减少副作用.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.审计单元中的审计单元.癌细胞癌细胞癌细胞细胞活力细胞活力西斯普拉丁 (Cisplatin) 是一种在 MnTBAP 中.尼铁氨酸的使用方法

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