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饮食偏好与心血管疾病的关联:孟德尔的随机化研究
Mia D Lee1, Benjamin F Voight2,3,4
1Pharmacology Graduate Group, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA, USA.
Atherosclerosis plus
|June 11, 2025
概括
揭示了特定食物偏好与心血管疾病 (CVD) 风险之间的遗传联系. 肥胖是一个关键的调解者,强调饮食.
科学领域:
- 营养学就是营养学.
- 心血管流行病学心血管流行病学
- 统计遗传学 统计遗传学
背景情况:
- 心血管疾病 (CVD) 的易感性涉及遗传和环境因素,饮食是关键的可修改风险.
- 全基因组关联研究 (GWAS) 为探索饮食在心血管疾病中的作用提供了新的途径,超出了传统的观察性研究.
研究的目的:
- 使用遗传数据调查饮食偏好和心血管疾病之间的因果关系.
- 为了确定可能因果影响心血管疾病风险的特定饮食习惯.
- 探索饮食与心血管疾病关系中的中介因素,如肥胖和教育程度.
主要方法:
- 利用了38种饮食偏好和7种常见心血管疾病的全基因组关联数据.
- 在因果推断和假设测试中采用孟德尔的随机化 (MR).
- 进行调解分析,以评估饮食偏好对心血管疾病的间接影响.
主要成果:
- 在八种饮食偏好和三种心血管疾病终点 (P <1.88 × 10−4) 之间确定了10个显著的因果关系.
- 按体重指数 (BMI) 衡量的肥胖是几个饮食与心血管疾病相关性的重要调解者.
- 学历水平成为了米斯利偏好和外围动脉疾病 (PAD) 风险之间的关联的调解者.
结论:
- 提供基因证据支持特定饮食偏好与心血管疾病风险之间的因果关系.
- 强调肥胖作为从饮食到心血管疾病的通路中的共同调解者的作用.
- 建议了解个体的饮食偏好及其遗传基础对于心血管疾病预防策略至关重要.
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