儿童重症监护中的持久性乳病的患病率和发生率
Amani Nabri1, Abdulaziz Alshehri2, Sarah A Alfurayj1
1College of Medicine, Dar Al Uloom University, Riyadh, SAU.
Cureus
|June 11, 2025
概括
阿尔法多纳治疗可能会减少儿科重症监护病房中新出现的持久性脱血病例. 虽然患病率相似,但多尔纳斯的发病率较低,这表明它有保护性作用,可以防止阿特莱克塔斯的进展.
科学领域:
- 关键护理医学 关键护理医学
- 儿科肺病学 儿科肺病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 持久性乳化症是儿科重症监护中的一个重大问题,关于其流行和发病率的数据有限.
- 了解风险因素和治疗疗效对于改善住院儿童的治疗结果至关重要.
研究的目的:
- 为了确定儿科重症监护室 (PICU) 患者持续性乳腺脱落的患病率和发病率.
- 评估dornase alfa治疗对该人群中持续性乳糖脱离症的潜在影响.
主要方法:
- 从2020年2月到2023年10月在PICU进行的回顾性观察研究.
- 纳入患有持续超过48小时的肺性脱氧症的儿科患者,将多纳斯αα治疗与未治疗组进行比较.
- 统计分析包括t测试,奇平方测试,相关性和回归分析,以评估流行率,发病率和预测因素.
主要成果:
- 持久性乳化酶的患病率在多纳酶组为48.18%,在非多纳酶组为51.82%.
- 新病例发生率在dornase组 (26.4个新病例) 与非dornase组 (71.5个新病例) 相比显著较低.
- 在高危儿科患者中,dornase alfa治疗似乎可以预防乳糖脱落症的进展.
结论:
- 多纳斯阿尔法治疗显示出降低儿科重症监护中新出现的持久性乳腺脱离症的发生率的潜力.
- 虽然患病率相似,但较低的发病率表明dornase可能会抑制atelectasis的进展.
- 需要进一步的研究来确定因果关系,并调查由于回顾性设计对患者整体存活时间的影响.
更多相关视频
06:15Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
49.7K
05:50International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure
Published on: March 12, 2020
13.5K
相关概念视频
Pulmonary Cycle: Exhalation
1.5K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.5K
Pneumonia I: Introduction
214
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
214
Pneumonia III: Complications and Assessment
182
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
182
Pneumothorax-II
126
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
126
Pneumonia V: Nursing management and Prevention
1.9K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
1.9K
Acute Respiratory Failure-III
162
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
162
