在没有焦点的情况下呈现发烧的儿童中,肠热的早期预测因素:一项前性研究
Priyanka Kala1, Rekha Mittal2, Shyam Kukreja3
1Pediatrics and Neonatology, Max Super Speciality Hospital, New Delhi, IND.
Cureus
|June 11, 2025
概括
在没有血液培养的情况下,可以使用临床症状和基本实验室测试来早期预测儿童的肠热 (EF). 这种方法可以帮助减少在资源有限的环境中不必要的抗生素使用.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 血液培养是诊断肠热 (EF) 的黄金标准,但往往无法获得.
- 对诊断的限制导致过度使用抗微生物药物.
- 早期和准确的EF诊断至关重要,特别是在资源有限的环境中.
研究的目的:
- 用临床特征和基本实验室参数来确定EF是否可以在早期预测.
- 探索一种替代的诊断方法,绕过血液培养的需要.
- 确定儿童EF的独立预测因子.
主要方法:
- 德里的前性队列研究,涉及6个月至15岁的儿童发烧.
- 根据血液培养结果和随后的诊断,儿童被分类.
- 使用后勤回归分析来确定EF的独立预测因素.
主要成果:
- 在350名儿童中,有73名儿童的血液培养确认了EF.
- 独立预测EF包括:发烧持续时间>4天,发烧上升趋势,涂层的舌头,壮,C反应蛋白 (CRP) 的升高,血清葡萄糖酸氨酸酶 (SGPT) 的升高和绝对乙氨基.
- 临床和实验室发现有效地预测了研究群体中的EF.
结论:
- 使用临床特征和简单的实验室测试,可以对肠热进行早期预测.
- 这种方法在资源有限的环境中是有价值的,因为血液培养不容易获得.
- 临床预测有可能减少经验性抗生素过度使用.
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