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Updated: Jun 12, 2025

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
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RNF219 戒指指域突变体驱动相分离以封装CCR4-NOT并促进细胞增殖

Chen Chen1, Chenghao Guo1, Ke Fang1

  • 1Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing, China.

Cell proliferation
|June 11, 2025
PubMed
概括

在RING指蛋白219 (RNF219) 中的突变可以导致它形成凝结物,抑制CCR4-NOT死酶活性并促进细胞增殖. 这表明RNF219突变的新致病机制.

关键词:
CCR4 - 没有没有这就是LLPS.在RNF21919中,突变物是突变物中的一个.

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