人类胎盘及其在生殖结果中的作用被重新审视
Irving L M H Aye1,2,3, Stephen Tong4,5, D Stephen Charnock-Jones1,2
1Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, United Kingdom.
Physiological reviews
|June 11, 2025
概括
胎盘功能障碍影响胎儿发育,但其原因尚不清楚. 先进的人类细胞模型和奥米克分析为了解和治疗妊娠并发症提供了新的途径.
科学领域:
- 生殖生物学 生殖生物学
- 孕产妇和胎儿的医学
- 基因组学和蛋白质组学
背景情况:
- 胎盘功能对于胎儿的生长和发育至关重要.
- 胎盘功能障碍对全球疾病负担做出了重大贡献,但其潜在机制尚不清楚.
- 目前的诊断方法,如超声波多普勒流速计,以及新兴的生物标志物在识别和描述胎盘功能障碍方面存在局限性.
研究的目的:
- 突出迫切需要改进的方法来理解和解决胎盘功能障碍.
- 探索omics技术和先进的人体细胞模型在推进研究方面的潜力.
- 为了确定新的治疗点,并改善妊娠并发症的临床结果.
主要方法:
- 审查目前对胎盘功能的临床评估方法.
- 探索omics方法 (例如,母亲的血液omics,胎盘组织的空间omics).
- 评估新型人类细胞模型,包括热囊细胞干细胞和有机体.
主要成果:
- 评估胎盘功能的现有方法在过去二十年中得到了有限的改进.
- 奥米克斯对母亲血液的分析显示,有望识别出更好的疾病预测因子.
- 与动物模型相比,先进的人类细胞模型为假设测试提供了更具临床相关性的平台.
结论:
- 对于针对胎盘的新型疗法有着至关重要的需求.
- 欧米克和先进的人类细胞模型代表了阐明胎盘功能障碍机制的有希望的策略.
- 这些创新方法可能会改善胎盘相关妊娠并发症的诊断和治疗.
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