血压和晚期怀孕 在MADRES研究中循环miRNAs
Elizabeth C Anderson1, Meghan E Muse1, Zhongzheng Niu2
1Department of Epidemiology Geisel School of Medicine at Dartmouth Lebanon NH.
Journal of the American Heart Association
|June 11, 2025
概括
即使在亚临床范围内,母亲的高血压也会改变循环中的细胞外囊泡粒子 (EVP) 微RNA (miRNAs),这与不良怀孕和心血管结果有关. 这些发现突出了EVP miRNAs作为监测孕产妇健康的潜在生物标志物.
科学领域:
- 生殖生物学和心血管健康.
- 怀孕并发症的生物标志物的发现.
背景情况:
- 循环细胞外囊泡颗粒 (EVP) 微RNA (miRNA) 与心血管风险和不良出生结果有关.
- 妊娠高血压障碍 (HDP) 增加了母亲和儿童的风险,并与母亲循环EVPmiRNA水平的改变有关.
- 怀孕期间亚临床血压升高 (BP) 和母亲循环的EVP miRNAs之间的关系尚不清楚.
研究的目的:
- 调查妊娠高血压疾病 (HDP) 与孕产妇血压轨迹 (包括亚临床范围) 和怀孕期间循环EVPmiRNA水平之间的关联.
- 在MADRES (环境和社会压力因素对母亲和发育风险) 研究中,在怀孕期间识别对孕产妇血压敏感的特定EVPmiRNA.
主要方法:
- 潜阶级轨迹建模确定了三个母体血压轨迹:低,中等和高.
- 使用NanoString nCounter平台对来自母亲血液的798个miRNA进行量化,平均妊娠年龄为31.6周.
- 与共变量调整的回归模型评估了HDP亚型,BP轨迹和单个miRNA水平之间的关联.
主要成果:
- 慢性高血压与miR-1185-2-3p水平的增加有关,这是一个与动脉硬和早产相关的胎盘特异性miRNA.
- 高血压与某些胎盘表达的miRNAs水平较低有关,这些miRNAs以前与更长的妊娠时间有关.
- 与BP相关的EVPmiRNA的基因在与血管炎症,氧化应激,内皮功能障碍和胎盘功能相关的途径中得到丰富.
结论:
- 流通的胎盘表达的EVPmiRNAs,此前与不良分娩和心血管结果有关,对孕期母亲高血压敏感.
- 这些发现表明,EVP miRNAs可以作为敏感的生物标志物来监测孕妇的血压,包括在妊娠期间的亚临床范围.
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