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相关概念视频

ECG Interpretation of Arrhythmias I: Sinus Arrhythmias01:16

ECG Interpretation of Arrhythmias I: Sinus Arrhythmias

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Arrhythmias are disturbances in the heart's rhythm that lead to abnormal heartbeats. These irregularities can originate from different parts of the heart and are classified based on their origin and nature.
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
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Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
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Mechanism of Cardiac Arrhythmias01:28

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Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
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Decreased pulse rate01:14

Decreased pulse rate

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Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
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Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
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衰老和鼻节功能障碍:机制和未来的方向

Thassio Mesquita1, Rodrigo Miguel-Dos-Santos1, Eugenio Cingolani1

  • 1Cedars-Sinai Medical Center, Smidt Heart Institute, 8700 Beverly Boulevard, Davis Building, Los Angeles, CA 90048, U.S.A.

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概括
此摘要是机器生成的。

衰老会通过改变鼻腔节点 (SAN) 来导致心率下降. 本综述探讨了与年龄相关的SAN功能障碍 (SND) 机制以及改善心脏健康的未来治疗目标.

关键词:
老化的老化 衰老的老化心脏节律失常 心脏节律失常心脏导电系统的心脏导电系统阴节点的阴节点鼻节的功能障碍 鼻节的功能障碍

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科学领域:

  • 心脏病学 心脏病学
  • 老年学是一门学科.
  • 身体生理学 身体生理学

背景情况:

  • 老龄化自然会降低心率,影响心脏的主要起器 - - 鼻腔节点 (SAN).
  • 在65岁以后,鼻腔节点功能障碍 (SND) 的发生率急剧上升,导致昏迷等症状.
  • 增加寿命需要了解与衰老相关的SND,以获得有效的治疗方法.

研究的目的:

  • 审查有关SAN功能与年龄相关的变化的当前知识.
  • 要突出对SND有贡献的离子和结构改造.
  • 确定新的治疗策略的未来研究方向.

主要方法:

  • 关于衰老和心脏电生理学的文献综述.
  • 对SAN结构和功能研究的分析.
  • 综合研究与年龄相关的离子通道变化.

主要成果:

  • 衰老导致SAN内部发生显著的离子和结构变化.
  • 这些变化导致心脏起器功能下降,对心律失常的易感性增加.
  • 目前的理解指出了受衰老影响的特定分子通路.

结论:

  • 与年龄相关的SAN功能障碍是老年病学中的一个关键问题.
  • 对与衰老相关的SND分子机制的进一步研究至关重要.
  • 开发针对SND的向疗法对于改善老年人的生活质量至关重要.