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微RNA在骨髓缩性肥胖/肥胖中的作用:一个范围审查

Mariantonia Braile¹, Adriano Braile^2,3,4, Chiara Greggi⁴

¹Department of Woman, Child and of General and Specialized Surgery, Università Degli Studi Della Campania "Luigi Vanvitelli", 81031 Napoli, Italy.

|June 11, 2025

概括

微RNAs (miRNAs) 显示出作为骨类肥胖症候群 (OSO) 的生物标志物具有前途,这种疾病涉及骨和肌肉损失与多余脂肪. 运动和营养干预措施可能会影响miRNA表达以管理OSO.

科学领域:

生物化学生物化学
老年学是指老年学的学科.
分子生物学分子生物学

背景情况:

骨髓缩性肥胖症候群 (OSO) 或骨髓缩性肥胖症 (OSA),涉及与多余脂肪同时发生的骨和肌肉损失.
这种情况导致身体功能受损和代谢障碍.
最近的研究涉及微RNA (miRNA) 在OSO/OSA病理生理学中,观察到差异表达.

研究的目的:

审查目前关于微RNAs (miRNAs) 在骨髓质肥胖症 (OSO) 综合征中的作用的文献.
确定潜在的miRNA生物标记物和OSO/OSA管理的治疗点.

主要方法:

在主要的文献数据库 (Embase,PubMed,Scopus) 进行了系统的文献搜索.
适用资格标准来选择相关的研究进行分析.

主要成果:

在审查了1311个初始记录后,包括了19项研究.
发现体育炼和营养因素调节miRNA表达,对老龄化人口有益.
miRNAs被认为是肌肉缩和与衰老相关的生物过程的关键指标,并得到动物研究的支持.

结论:

微RNAs (miRNAs) 代表了 osteosarcopenic 肥胖症候群 (OSO) 的潜在生物标志物和治疗点.
抵抗训练和持续炼等干预措施可能会影响miRNA的表达,提供减轻OSO影响的策略.

关键词:

微型RNAs (miRNAs) 是一种微型RNA.骨质疏松症 (osteosarcopenia) 是一种骨质疏松症.骨髓瘤性脂肪性 (OSA) 是一种疾病.骨髓瘤性肥胖症 (OSO) 是一种疾病.

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