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短期和长期内皮质炎症具有不同的影响,并与细胞衰老的特征重叠

Barbora Belakova¹, José Basílio², Manuel Campos-Medina¹

¹Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.

|June 11, 2025

概括

细胞衰老和炎症在内皮细胞中共享分子通路. 炎症加剧衰老,影响心血管健康和损害细胞功能.

科学领域:

内皮细胞生物学内皮细胞生物学
细胞衰老细胞衰老
炎症研究的研究.

背景情况:

细胞衰老和炎症与衰老和疾病有关.
内皮细胞在心血管健康中起着至关重要的作用.
内皮细胞中衰老和炎症之间的相互作用需要进一步阐明.

研究的目的:

研究细胞衰老与人类静脉内皮细胞 (HUVECs) 炎症之间的相互作用的分子机制.
为了将衰老的HUVECs的基因表达特征与急性或慢性TNFα介导炎症的基因表达特征进行比较.
验证与衰老和炎症相关的关键分子和功能变化.

主要方法:

在HUVEC中诱导复制性和辐射压力诱导的衰老.
RNA测序以分析基因表达变化.
实验验证基因表达和功能测试 (增殖,细胞因子分泌,伤口愈合).

主要成果:

衰老和慢性炎症都诱导了与内皮-介质细胞过渡 (EMT) 和炎症途径相关的基因的上调.
慢性炎症显示出明显的EMT特征,而急性炎症则激活了经典的炎症反应.
衰老和慢性炎症细胞表现出减少的增殖,增加的IL-6 / IL-8分泌和受损的伤口愈合.

结论:

细胞衰老和炎症在HUVEC中具有共同的分子通路,包括EMT和炎症信号.
炎症加剧与衰老相关的变化,导致内皮功能障碍.
研究结果提供了有关年龄的心血管病理和潜在的治疗点的见解.

关键词:

这是一种急性炎症.慢性炎症是一种慢性炎症.基因组丰富分析分析中细胞过渡转变.分子签名分子签名它们的扩散和扩散.衰老是一种老化.翻译学翻译学翻译学翻译学伤口愈合伤口愈合

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