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Updated: Jun 14, 2025

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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通过R-2-基氨酸介导的KDM4A的抑制会损害端粒完整性

Florence Couteau1, Laurence M Gagné1,2, Karine Boulay1

  • 1Maisonneuve-Rosemont Hospital Research Centre, Montréal, Qc, H1T 2M4, Canada.

Nucleic acids research
|June 11, 2025
PubMed
概括

突变的异酸盐脱酶 (IDH1/2) 产生R-2HG,抑制KDM4A. 这导致端粒功能障碍和基因组不稳定,推动脑癌的发展.

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