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实施APOL1基因测试对活捐赠者的临床评估的背景因素
James L Merle1, Marissa C Kuo2, Jessica Gacki-Smith3
1Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA.
概括
APOL1遗传检测和咨询计划增强了活着的脏捐赠者的知情同意. 解决实施障碍是维持和公平护理的关键.
科学领域:
- 移植研究 移植研究
- 实施科学 实施科学
- 遗传咨询 遗传咨询 遗传咨询
背景情况:
- 活体供体移植 (LDKT) 是对末期病的最佳选择.
- 黑人活体捐赠者面临更高的捐赠后脏疾病风险.
- 了解LDKT中的差异至关重要.
研究的目的:
- 评估APOL1遗传检测和咨询计划的实施情况.
- 确定影响采用和维持的因素.
- 改善活体捐赠者的知情决策.
主要方法:
- 在两个移植中心进行混合方法评估.
- 使用实施研究综合框架进行半结构面试.
- 与移植科医生进行调查.
主要成果:
- 促进者:临床调整,组织支持,文化敏感咨询.
- 障碍:时间限制,需要基于证据的指导方针.
- 报告的高可接受性,适当性,可行性和可持续性.
结论:
- 确定了APOL1计划维持的促进者和障碍.
- 解决障碍对于改善捐赠者的知情同意至关重要.
- 扩展APOL1计划所需的系统级策略.
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