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通过激光合成银纳米颗粒的体外抗菌活性,对抗牙腐烂细菌 (S-mutans)

Mays S Tareq¹, Ali K Hameed², Ali H Saleem³

¹College of Applied Sciences, University of Technology, Baghdad, Iraq. mays.s.tareq@uotechnology.edu.iq.

Lasers in medical science

|June 11, 2025

概括

激光合成的银纳米粒子对S. mutans. 产生强大的抗菌作用. 较小的纳米粒子 (20纳米) 显示出增强的疗效,由于银离子氧化,在两个月后观察到最佳活性.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
微生物学微生物学

背景情况:

牙损伤主要是由突变性菌株 (Streptococcus mutans) 引起的,这对口腔健康构成了重大挑战.
开发新的抗菌剂对于对抗耐药细菌菌株至关重要.
银纳米粒子 (Ag NPs) 以其广泛的抗微生物特性而闻名.

研究的目的:

使用双激光技术合成银纳米颗粒 (AgNP) 进行比较抗菌评估.
研究激光参数对Ag NP特征和对S. mutans的抗菌功效的影响.
探索老化对激光合成的AgNP的抗菌活性所起的作用.

主要方法:

通过脉冲激光切除 (Nd:YAG) 和随后的激光碎片 (光纤激光) 来合成银纳米粒子.
描述涉及UV-Vis光谱学,泽塔电位,传输电子显微镜 (TEM) 和原子力显微镜 (AFM).
评估了对S. mutans的抗菌活性,确定了抑制区和最小有效度.

主要成果:

TEM揭示了球形的AgNP,平均尺寸约为20nm.
AFM表示平均直径为34nm (Nd:YAG) 和16nm (光纤激光),粗度不同.
较小的AgNP (约20nm) 显示出优越的抗菌活性,在最低有效度为6μg/ml时达到25mm的抑制区.
抗菌功效随着长达两个月的老化而增加,归因于银离子氧化.

结论:

双激光合成提供了一种可控制的方法,用于生产具有可调节性质的AgNP.
较小的Ag NP大小与增强的抗菌疗效与S. mutans直接相关.
老化过程增强了AgNP的抗菌性能,突出了它们在牙科应用中的潜力.

关键词:

具有抗菌活性,具有抗菌活性.纤维激光器纤维激光器血共振是指等离子体的共振.在液体中脉冲激光切除 (PLAL)银纳米粒子 (AgNP) 是一种

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