针对细胞癌的向治疗耐药性研究的趋势和热点:一个图书统计和可视化分析
Ziqian Wang1,2, Xiaodu Xie1, Ze Wang1
1Department of Urology, Daping Hospital, Army Medical University, No. 10 Changjiang Zhilu, Chongqing, 400042, China.
Discover oncology
|June 11, 2025
概括
这项文献计量研究分析了细胞癌 (RCC) 中的向治疗耐药性. 关键发现强调瘤微环境,癌症干细胞和组合疗法是未来研究改善RCC治疗结果的关键领域.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 分子向疗法对于转移性细胞癌 (mRCC) 至关重要,但面临药物耐药性和瘤复发的挑战.
- 尽管进行了广泛的研究,但缺乏针对细胞癌 (RCC) 针对性治疗耐药性的综合文献计量分析.
研究的目的:
- 进行对细胞癌 (RCC) 针对性治疗耐药性的研究的文献分析.
- 确定这一领域的关键趋势,有影响力的作者,机构和研究热点.
主要方法:
- 从Web of Science核心集合 (2004-2024) 中对1081个英语出版物的图书统计分析.
- 使用VOSviewer和CiteSpace分析出版趋势,国家/地区贡献,作者/机构影响以及关键词的共同出现.
- 检查了研究主题,调节分子和与RCC中向治疗耐药性相关的分子机制.
主要成果:
- 美国,中国和意大利在出版方面领先. 确定了关键机构和作者.
- 突出的研究主题包括瘤微环境,组合疗法,癌干细胞和上皮-介质细胞过渡.
- 微RNA (miRNA) 和抗PD-L1/PD-1与向药物的协同作用被强调为关键的分子机制.
结论:
- 针对细胞癌 (RCC) 针对性治疗耐药性的研究表明,这一趋势正在迅速增加.
- 瘤微环境,癌干细胞,表皮-介质细胞过渡,miRNA和组合免疫疗法是重点关注的关键领域.
- 未来的研究可能会确定新的治疗点,以克服耐药性并改善mRCC患者的治疗结果.
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