在战争时期的乌克兰,艾滋病毒暴露前预防 (PrEP) 摄入量和持续性:从规模化的PrEP计划中分析数据
Ellis G Moon1, Alyona P Ihnatiuk2, Anna P Kazanzhy2
1Department of Epidemiology, University of Washington, Seattle, WA, USA.
AIDS and behavior
|June 11, 2025
概括
乌克兰 乌克兰 乌克兰 乌克兰
科学领域:
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
- 预防艾滋病毒 预防艾滋病毒
背景情况:
- 乌克兰持续的战争严重影响了包括预防艾滋病毒在内的卫生计划.
- 了解战时使用和遵守艾滋病毒暴露前预防 (PrEP) 对于维持公共卫生收益至关重要.
研究的目的:
- 评估战争期间乌克兰个人每日暴露前预防 (PrEP) 的吸收和持续性.
- 确定与PrEP停药相关的因素,包括性别,主要人口群体,年龄和地理位置 (前线与非前线).
主要方法:
- 从2022年10月到2023年9月,对94家诊所的4,537名每日PrEP新用户进行了观察性研究.
- 使用卡普兰-梅尔曲线和性别分层的考克斯回归分析来确定prep持久性和中止风险.
- 准备剂持续性被定义为在预期日期的7天内补充药物.
主要成果:
- 总的来说,六个月的PrEP持续时间为37.3%.
- 与男性发生性关系的男性 (MSM) (28.6%),18至25岁的年轻人 (17.2%) 和前线地区的居民 (15.6%) 的持续性明显较低.
- 性工作者 (SW) 表现出很高的持久性 (81.5%),与不和的夫妇相比,戒断风险较低 (aHR:0.22). 年轻人和前线地区的年轻人表现出更高的戒断风险.
结论:
- 尽管有战争时期的挑战,但乌克兰的PrEP计划表现出了性.
- 有针对性的干预措施对于改善PrEP在年轻成年人 (18-25岁) 和前线地区的人群中的持续性至关重要.
- 需要持续支持和量身定制的战略,以确保在冲突期间脆弱人群持续获得艾滋病毒预防.
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