12个月后抗逆流粘膜剥离疗法的有效性和安全性
Krithi Krishna Koduri1, Neeraj Singla1, Rajesh Goud Maragoni1
1Department of Medical Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, 500 082, India.
概括
抗逆流性粘膜切除 (ARMA) 在12个月内显著降低了与质子抑制剂 (PPI) 相关的胃食道逆流性疾病 (GERD) 患者的症状,改善了他们的生活质量. 最少侵入性的ARMA手术显示出了有利的安全性.
科学领域:
- 胃肠病学 胃肠病学
- 最少侵入性手术的方法
- 逆流性疾病管理管理
背景情况:
- 依赖质子抑制剂 (PPI) 的胃食道逆流性疾病 (GERD) 影响患者,尽管接受了酸抑制治疗,但症状持续.
- 抗反流性粘膜切除 (ARMA) 提供了一种最小侵入性的治疗选择,用于管理GERD.
- 评估ARMA的长期安全性和有效性对于其临床应用至关重要.
研究的目的:
- 评估抗逆流粘膜切除 (ARMA) 的安全性和有效性,对那些依赖质子抑制剂 (PPI) 的胃食道逆流病 (GERD) 的患者.
- 在ARMA后12个月评估症状减少和生活质量改善.
- 根据ARMA程序分析客观的反流参数.
主要方法:
- 这是一项单一中心前性研究,涉及216名依赖PPI治疗的患者.
- ARMA使用标准化混合技术 (下粘膜提升后进行切除) 进行.
- 在基线,3个月和12个月评估GERD与健康相关的生活质量 (HRQL) 评分.
- 在基线和12个月进行的24小时pH阻抗监测,以测量酸暴露时间 (AET) 和DeMeester得分.
主要成果:
- 在GERD-HRQL得分显著改善,从基线43.8到12个月后的8.3 (p<0.001).
- 胃灼热和吐得分显著降低,12个月后AET和DeMeester得分下降 (p<0.001).
- 没有报告任何重大不良事件,这表明ARMA的安全性概况良好.
结论:
- 抗逆流性粘膜切除 (ARMA) 提供持续的症状缓解,并提高PPI依赖的GERD患者在12个月后的生活质量.
- 该程序以其简单性,可访问性和有利的安全概况为特征.
- 对于精选的GERD患者来说,ARMA是一个可行的最小侵入性治疗选择.
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