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在患有三阴性乳腺癌的患者中,种族和民族的ERBB2-低表达

Astrid Botty van den Bruele^1,2, Kerri-Anne Crowell^2,3, Samantha M Thomas^2,3

¹Department of Surgery, Duke University School of Medicine, Durham, North Carolina.

JAMA network open

|June 11, 2025

概括

三重阴性乳腺癌 (TNBC) 结果因ERBB2低表达和种族而异. 低ERBB2与总体较低的病理完整反应 (pCR) 有关,但在不同患者群体中,生存率有很大差异.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
健康差异在健康上的差异

背景情况:

在三阴性乳腺癌 (TNBC) 结果中的种族和种族差异已被记录.
瘤生物学,包括ERBB2表达,可能会影响这些差异.
在不同种族和种族群体的TNBC结果中ERBB2-低表达的作用需要进一步研究.

研究的目的:

为了确定TNBC中ERBB2-低表达是否因种族和种族而异.
评估ERBB2-低表达与TNBC患者的病理完整反应 (pCR) 和整体存活 (OS) 之间的关联.
探索这些关联如何在种族和种族群体之间存在差异.

主要方法:

使用国家癌症数据库 (2010-2019) 进行回顾性队列研究.
包括接受新辅助化疗治疗的I-III期TNBC的成年女性患者.
根据免疫组织化学得分 (1+或2+) 定义的ERBB2-低和非增强的in situ杂交;ERBB2-零定义的IHC 0.

主要成果:

在31,888名TNBC患者中,超过一半的ERBB2表达低.
低ERBB2表达与较低的pCR率 (28.6%与30.8%,P<.001) 相关.
西班牙裔患者在ERBB2状态中表现出更高的ERBB2-零TNBC率和更高的PCR率. 无论ERBB2状态如何,黑人患者的pCR和OS都较低. 与ERBB2-零相比,亚裔和白人患者的ERBB2-低表达显示了延长的OS.

结论:

低ERBB2表达及其对TNBC结果的影响在种族和种族群体之间有很大差异.
这些发现强调了需要研究ERBB2低表达在多样化的TNBC患者群体的生物学基础.
了解这些变异对于解决乳腺癌治疗中的健康差异至关重要.

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