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Chun-Wei Pan¹, Yazan Abboud², Amit Chitnis³

¹Department of Internal Medicine, John H. Stroger Hospital of Cook County, Chicago, Illinois.

JAMA network open

|June 11, 2025

概括

酒精相关性肝病 (ALD) 死亡率在美国显著上升,特别是在女性,年轻人和美洲原住民中. 需要紧急的公共卫生干预措施来应对这些令人担忧的趋势.

科学领域:

肝病学肝病学是一种肝病学.
公共卫生公共卫生
流行病学流行病学

背景情况:

酒精相关性肝病 (ALD) 是美国的一个关键的公共卫生问题,在肝硬化死亡和肝移植的重大贡献.
对ALD的死亡率显示出令人担忧的增加,特别是在COVID-19大流行开始后.

研究的目的:

从1999年到2022年,全面分析美国ALD死亡率的国家趋势.
调查基于性别,种族,种族和年龄的ALD死亡率的差异.

主要方法:

对疾病预防控制中心流行病学研究 (WONDER) 死亡数据库 (1999-2022) 广泛在线数据的回顾性横截面分析.
包括所有50个州和哥伦比亚特区的25岁及以上个人的死亡证明.
根据年龄调整的年均死亡率根据人口因素计算和分层,并使用Joinpoint回归来确定趋势.

主要成果:

总的ALD死亡人数超过436,000人,死亡率从1999年至2022年之间每10万人口中的6.71人增加到12.53人.
从2018年到2022年 (APC8.94%) 观察到死亡率显著加速.
妇女,年轻人 (25-44岁) 和美洲印第安人/阿拉斯加原住民群体的ALD死亡率不成比例地快速增加.

结论:

在美国,在不同的人口群体中,ALD死亡率显著增加.
在妇女,年轻人和美国印第安人/阿拉斯加土著人口中注意到了有关趋势.
针对性公共卫生干预和加强监测至关重要,考虑到与大流行有关的酒精消费的转变.

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