大麻戒断和精神病重症监护
Aliyah Malik1, Hitesh Shetty2, Dominic Oliver3,4
1Department of Addictions, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom.
JAMA psychiatry
|June 11, 2025
概括
在严重精神疾病患者中使用大麻会增加在戒断期间转移到精神病重症监护室 (PICU) 的风险. 这种风险在妇女和老年人中更高.
科学领域:
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
- 公共卫生 公共卫生
背景情况:
- 大麻的使用在患有严重精神疾病的人群中很普遍.
- 大麻戒断综合征 (CWS) 可以表现为焦虑和易怒等症状,通常在戒断后3-5天达到顶峰.
- 这种人群的不良结果可能与CWS有关,而不仅仅是大麻使用本身.
研究的目的:
- 调查入院前大麻使用与转移到精神病重症监护室 (PICU) 的风险之间的关联.
- 为了确定这种风险是否在已确定的大麻戒断风险期 (入院后3-5天) 中升高.
主要方法:
- 一项回顾性队列研究,利用来自伦敦4家精神病医院 (2008-2023) 的二级心理健康护理数据库.
- 包括入住普通精神病房和PICU的成年患者.
- 通过使用自然语言处理和手动审查,通过临床记录确定大麻的使用. 结果使用多变量模型进行分析,并根据主要的人口和临床因素进行调整.
主要成果:
- 分析了超过52,000个入院病例;其中9.0%涉及PICU入院.
- 大麻使用者的PICU入院概率明显更高 (aOR, 1.44).
- 在入院后3-5天内转移到PICU更常见于大麻使用者 (31.0%vs24.2%,aOR,1.36),特别是在女性和35岁以上的个人中.
结论:
- 在精神病患者入院前使用大麻与PICU转移的风险增加有关,特别是在CWS风险期间.
- 大麻戒断综合征可能会加剧精神疾病,导致更高的护理需求.
- 这些发现强调了在治疗严重精神疾病患者时考虑大麻使用和潜在戒断的重要性.
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