药物使用与表型衰老之间的纵向关联:来自巴尔的摩老龄化纵向研究的见解
Bowen Tang1,2,3, Perry Kuo3, Ann Zenobia Moore3
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
概括
某些药物可能会减缓表型衰老,这是生物衰老的衡量标准. 这项研究发现维生素D,双酸盐,质子抑制剂,甲状腺激素和 thiazides 与减少衰老标志物有关.
科学领域:
- 老年学和老年医学是老年学和老年医学.
- 药理学 药理学是指药理学的学科.
- 衰老的生物标志物
背景情况:
- 关于药物对表型衰老的影响的基于人口的数据很少.
- 巴尔的摩长度老龄化研究 (BLSA) 为本次调查提供了数据.
- 现型衰老 (PA) 反映了多个生理领域的生物衰老.
研究的目的:
- 调查常用药物的使用与表型衰老标志物的变化之间的关联.
- 确定可能影响衰老速度的特定药物类别.
主要方法:
- 使用Klemera-Doubal (KD) 方法计算表型衰老标志物,评估身体组成,能量,平静机制以及神经可塑性/神经退行.
- 在使用条件概括估计方程 (cGEE) 分析了27种药物类别和PA标记物变化之间的关联.
- 检查了个体内部的变化,以控制遗传和生命早期的因素,并对随时间变化的共变量进行调整.
主要成果:
- 五种药物类别与降低的PA标志物有显著的关联.
- 维生素D,双酸盐和质子抑制剂与特定领域的衰老缓慢有关.
- 甲状腺激素和 thiazides 与多个 PA 领域的减少有关,包括身体组成,能量和神经可塑性/神经退行.
结论:
- 某些药物可能会对表型衰老产生保护作用.
- 这些发现突出了调节衰老过程的潜在治疗点.
- 为了证实这些关联,需要在不同种群中进行进一步的验证.
更多相关视频
09:37A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
8.2K
10:13Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
13.7K
相关概念视频
02:20Longitudinal Research
11.9K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.9K
01:26Aging
39
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
39
01:26Longitudinal Studies
142
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
142
01:21Factors Affecting Drug Response: Overview
1.9K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.9K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
48
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
48
01:30Cognitive Development During Adulthood
66
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
66