后COPD:肺瘤可以修复吗?
J Michael Wells1, Jerry A Krishnan2, R Chad Wade3
1University of Alabama at Birmingham, Pulmonary, Allergy and Critical Care Medicine, Birmingham, Alabama, United States; jmwells@uabmc.edu.
概括
人类的肺部修复是可能的,鉴定了途径和新的临床试验设计,使得肺治疗研究成为可能. 研究人员现在可以测试现有药物的潜力,以再生膜结构和改善肺功能.
科学领域:
- 肺部医学 肺部医学
- 再生医学是一种再生医学.
- 临床试验 临床试验
背景情况:
- 临床观察表明,在人类中,膜结构修复或再生的可行性.
- 控制肺部修复的生物学途径已在临床前模型中确定,并在人类肺组织中得到验证.
研究的目的:
- 通过临床试验,评估人类肺气泡修复的科学前提.
- 利用成像,功能研究和生物标志物的进步来进行敏感的结果测量.
- 利用创新的平台临床试验设计,同时进行药物和生物标志物测试.
主要方法:
- 肺修复路径的特征 in vivo 和 ex vivo 模型.
- 在成年人肺组织中验证主要生物通路.
- 开发敏感的治疗效果和临床结果的治疗措施.
- 为异质人群实施平台临床试验设计.
主要成果:
- 参与肺修复的主要生物途径在人类肺组织中得到了验证.
- 有敏感的测量方法可用于评估瘤治疗效果.
- 平台临床试验允许同时测试多种药物和生物标志物.
结论:
- 在临床试验中,对人类肺气的肺修复的评估是可行的.
- 针对肺部修复途径的已批准的药物为肺提供了潜在的治疗选择.
- 试验设计和结果测量的进步促进了对肺复原的研究.
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