身体活动与心血管疾病相关的代谢和蛋白质生物标志物之间的关联
Örjan Ekblom1,2, Harry Björkbacka3, Mats Börjesson4,5
1Department of Physical Activity and Health, The Swedish School of Sport and Health Sciences (GIH), Stockholm, Sweden.
PloS one
|June 11, 2025
概括
身体活动水平影响心血管疾病风险标志物. 这项研究发现了不同类型的体力活动之间的特定关联,包括中度至剧烈的PA和久坐行为,以及众多蛋白质和代谢物生物标志物.
科学领域:
- 心血管疾病的研究研究.
- 代谢学和蛋白质学.
- 运动生理学 运动生理学
背景情况:
- 习惯性体力活动 (PA) 影响新陈代谢和平衡.
- 关于PA与心血管疾病 (CVD) 风险标志物之间的关联的详细知识有限.
- 了解这些联系对于预防和管理心血管疾病至关重要.
研究的目的:
- 确定加速仪评估的体力活动 (PA) 类与心血管疾病相关的蛋白质和代谢生物标志物之间的关联.
- 探索中度至强烈的PA (MVPA),低强度PA (LIPA),久坐行为 (SED) 和长时间的SED (prolSED) 与特定生物标志物之间的关系.
- 验证和发现PA和心血管疾病风险因素之间的新联系.
主要方法:
- 利用了SCAPIS队列 (发现) 和试点队列 (验证) 的横截面数据.
- 使用部佩戴的加速度计评估PA.
- 测量了血蛋白质生物标记物 (Olink CVD面板) 和代谢体标记物 (Nightingale NMR平台).
- 采用多重线性回归来控制混因子,错误发现率为5%.
主要成果:
- 八十五个代谢和四十三个蛋白质标记物显示出与PA类的显著关联.
- 高脂和低脂物种表现出与久坐行为和MVPA的明显关联.
- 确定了与MVPA (例如IL6,GDF15) 和SED (例如TIMP4,TNFR2) 的独特蛋白质组关联.
- 发现了SED/prolSED和MVPA的共享协会,用于LPL和LEP等标记.
结论:
- 在中年人群中,PA类与心血管疾病相关的代谢和蛋白质生物标志物之间存在特定的关联.
- 该研究发现了超出先前发现的新兴关联.
- 这些联系可能有助于解释PA和CVD之间的联系,为未来的实验设计和结果测量提供信息.
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