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Updated: Jun 15, 2025

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大规模的并行遗传扰动表明了粉样β过渡状态的能量结构

Anna Arutyunyan1, Mireia Seuma2,3, Andre J Faure3

  • 1Wellcome Sanger Institute, Cambridge, UK.

Science advances
|June 11, 2025
PubMed
概括

研究人员研究了阿尔茨海默病中的粉样β (Aβ42) 蛋白聚合. 他们绘制了Aβ42核的能量格局,揭示了一个结构化的过渡状态,可以启动疾病.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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