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麻症和认知障碍的风险:队列研究和孟德尔随机化分析
Tingting Sha1,2,3, Yuqing Zhang4,5, Jie Wei1,2,3,6,7
1Department of Orthopaedics, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, China, 86 84327326.
JMIR aging
|June 11, 2025
概括
肌肉损失的状况 - - 萨尔科佩尼亚,可能会导致认知障碍. 身体活动被确定为可以改变这种风险的关键因素,为干预提供了潜在的途径.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
背景情况:
- 认知障碍影响超过一半的60岁以上的人,治疗选择有限.
- 萨科佩尼亚和认知障碍之间的关系尚未得到充分证实,缺乏因果关系的证据.
- 识别可改变的认知衰退风险因素对于公共卫生至关重要.
研究的目的:
- 调查萨科佩尼亚和认知障碍之间的潜在因果关系.
- 利用队列数据和门德尔随机化 (MR) 的组合进行可靠的分析.
- 探索萨科佩尼亚和认知关系中的潜在调解因素.
主要方法:
- 分析了来自34457名参与者的英国生物库数据.
- 使用混合效应回归模型进行的观察分析,用于萨科佩尼亚和认知功能.
- 两个样本的孟德尔随机化 (MR) 来评估基因预测的肉骨指数和认知功能.
主要成果:
- 萨科佩尼亚与认知障碍有显著的关联,由流体智力下降表明.
- 遗传预测的尾肌肉量 (ALM),手握强度和步行速度的增加与改善的认知功能有关.
- 身体活动部分调解了ALM和手握强度对认知功能的影响.
结论:
- 建议将萨科佩尼亚作为潜在的认知障碍的因果风险因素.
- 身体活动成为从缩症到认知衰退的途径中显著可修改的调解者.
- 研究结果强调了维持身体活动对老年人群认知健康的重要性.
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