微环境可激活的长波长NIR-II可视化和协同治疗肺栓塞
Xue Meng1, Jianwen Song1, Zekun Du1
1State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Frontiers Science Center for Cell Responses, and College of Life Sciences, Nankai University, Tianjin 300071, China.
ACS nano
|June 11, 2025
概括
一个新的纳米平台使低氧触发的近红外成像和肺栓塞 (PE) 的联合治疗成为可能. 这种方法准确地可视化了血栓,并提高了治疗效率,并导致最少的并发症.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 心血管研究研究心血管研究
背景情况:
- 肺栓塞 (PE) 存在诊断和治疗方面的挑战.
- 准确的血栓可视化和有效的治疗非常重要.
- 目前对PE的治疗方法有局限性.
研究的目的:
- 开发一个微环境可激活的纳米平台,用于PE诊断和治疗.
- 为了使低氧触发的NIR-II光成像用于血栓可视化.
- 结合光热疗法 (PTT) 和硫化 (H2S) 释放以实现协同性血栓溶解.
主要方法:
- 在低氧条件下合成基于N-氧化物的分子探针,激活NIR-II光和光热特性.
- 将探头和热敏H2S供体封装成纳米粒子.
- 纳米颗粒的功能化与双色素用于血栓特异性向.
- 在使用NIR-II成像和PTT/H2S联合治疗的肺栓塞小鼠模型中进行评估.
主要成果:
- 该纳米剂通过可激活的NIR-II光成像实现了高度选择性和敏感的血栓可视化.
- 在PE小鼠模型中获得超过120的信号噪声比.
- 结合PTT和H2S疗法显著提高了血栓解压疗效,而不是尿酶.
- 该纳米剂在体内表现出极好的生物相容性,出血风险最小.
结论:
- 低氧反应的纳米平台为精确的PE诊断提供了一个有希望的策略.
- 综合治疗方法 (PTT和H2S释放) 显示出增强的血栓解毒疗效.
- 这个平台有可能用于治疗PE和其他心血管疾病.
相关概念视频
01:30Radiological Investigation II: MRI and Ventilation Perfusion Scan
105
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
105
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
88
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
88