分子瘤董事会治疗建议的现实结果
Federico Nichetti1,2, Marta Brambilla1, Matteo Duca1
1Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
JCO precision oncology
|June 11, 2025
概括
分子瘤板 (MTBs) 有助于选择向的癌症疗法. 符合分子向药物 (MTA) 资格但未接受治疗的患者的治疗结果较差,证实了MTB.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 临床试验分析
背景情况:
- 分子瘤板 (MTBs) 对于选择分子向剂 (MTAs) 至关重要.
- 由MTBs指导的MTAs在现实世界的临床实用性需要进一步确认.
研究的目的:
- 评估MTB讨论的患者中MTA的临床相关性和结果.
- 为了比较接受MTA治疗的患者和符合条件但未接受治疗的患者之间的生存指标.
主要方法:
- 追溯分析了1813个由米兰国家癌症研究所讨论的病例.
- 患者分为:符合条件并接受MTA治疗 (A组),符合条件但未接受治疗 (B组) 或不符合条件 (C组).
- 主要终点包括总生存率 (OS) 和无进展生存率 (PFS),PFSratio计算为A组.
主要成果:
- 在1,813例病例中,有458例 (25.2%) 可能有资格,有117例 (6.4%) 开始接受MTA治疗.
- 在MTA中,中位数PFS为12.0个月;中位数PFSratio为2.71,在接受MTA的患者中,在>1线治疗中,受益率为64%.
- 与B组和C组转移患者相比,A组 (接受治疗) 的生存时间明显更长 (aHR分别为2.21和1.71;P<.001).
结论:
- 由MTB驱动的疗法是必不可少的,因为没有接受MTA的合格患者的预后明显较差.
- 需要进一步努力,确保符合条件的癌症患者能够获得MTB选择的疗法.
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