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视网膜静脉封闭中,在最初良好的视觉敏度下,对内内阿弗利塞普特进行前性观察研究

Yusuke Koga¹, Yohei Otsuki², Kentaro Kojima¹

¹Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Retina (Philadelphia, Pa.)

|June 11, 2025

概括

在使用治疗和扩展方案的视网膜静脉封闭 (RVO) 患者中,静脉内注射aflibercept (IVA) 改善了视力和视网膜厚度. 分支RVO患者显示显著的视力敏度增加,而这两组都经历了视网膜敏感度的改善.

科学领域:

眼科医生眼科眼科
视网膜疾病视网膜疾病
血管眼科血管眼科

背景情况:

视网膜静脉封闭 (RVO),包括分支RVO (BRVO) 和中心RVO (CRVO),可能导致黄斑胀 (ME) 和视力丧失.
静脉内注射是一种常见的治疗方法,用于二次性ME和RVO.
在具有良好的初始视力敏度的RVO中,内阿弗利塞普特 (IVA) 的疗效需要进一步澄清.

研究的目的:

评估对BRVO和CRVO患者的内内阿弗利塞普特 (IVA) 注射的有效性,其最佳校正视敏度 (BCVA) 优于20/40.
在12个月内评估视觉敏度,视网膜敏感度和视网膜厚度的变化.

主要方法:

一项前性研究涉及61只眼睛 (44个BRVO,17个CRVO) 未经治疗的ME.
患者在治疗和延长 (TAE) 方案后接受了IVA注射,治疗间隔每四周调整一次.
最好的校正视敏度 (BCVA),中枢视网膜厚度 (CRT),视网膜灵敏度 (RS) 和平均偏差 (MD) 值在基线和随访点测量至12个月.

主要成果:

平均BCVA在12个月后在BRVO患者 (20/31至20/23) 中显著改善,但在CRVO患者 (20/28至20/24) 中没有显著改善.
视网膜敏感性在BRVO和CRVO患者中显著改善.
在这两组中,中枢视网膜厚度显著下降,而平均偏差值保持不变.

结论:

使用TAE治疗方案的静脉直肠阿弗利伯塞普 (IVA) 治疗表明,在具有良好的初始BCVA的患者中,RVO相关的ME的视觉预后有利.
在改善视力敏度方面,BRVO患者特别受益于IVA治疗.
在BRVO和CRVO中,IVA有效减少斑点并改善视网膜敏感性.

关键词:

一个自由的接受.微波测量仪的微波测量方法视网膜静脉闭塞视网膜静脉闭塞视力敏度视力敏度视力敏度

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