连文丹通过减轻氧化酸化功能障碍来减轻胃癌的发生
Xiuping Chi1, Yanru Song1, Sisi Wei1
1Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China; Key Laboratory of Tumor Prevention and Precision Diagnosis & Treatment of Hebei Province, Clinical Oncology Research Center, Shijiazhuang, Hebei 050011, China.
概括
温丹脱液 (WDD) 与连 (LQWDD) 结合,通过保护线粒体氧化酸化,抑制胃癌发生. 这种传统药物及其组成部分氨酸在治疗癌前胃病变方面表现有前途.
科学领域:
- 传统中国医药 传统中国医药
- 在瘤学瘤学.
- 线粒体生物学 线粒体生物学
背景情况:
- 温丹 (WDD) 在临床上被用作吐剂.
- 与WDD (LQWDD) 结合的Lian Qiao显示出协同效应.
- 初步观察表明,LQWDD可以缓解胃癌前病变,但机制尚不清楚.
研究的目的:
- 调查LQWDD对胃癌发生的疗效.
- 探索 LQWDD 作用的潜在机制.
主要方法:
- 对患者的回顾性分析和一种N-甲基-N9--N---- (MNNG) 诱导的老鼠胃癌模型.
- 蛋白质组和代谢组分析以确定机制和活性成分.
- 使用了网络药理学,HPLC-MS,海马分析和RNA测序.
主要成果:
- 在老鼠和患者中,LQWDD阻碍了胃癌发生.
- LQWDD保护了氧化酸化 (OXPHOS) 途径,逆转了MNNG诱导的功能障碍.
- 奎尔和凯姆菲罗尔被确定为活性成分,奎尔激活AMPK信号传递.
结论:
- 线粒体OXPHOS功能障碍是胃癌发生的关键因素.
- 通过减轻OXPHOS损伤,LQWDD和Quercetin可以抑制胃癌发生.
- 对于胃癌前期病变来说,LQWDD是一种有前途的治疗方法.
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